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The application of modern analytical techniques to drug testing provides an important criminal scientific basis for the investigation of drug cases and the conviction and sentencing of drug traffickers. Drug testing methods include immunoassay, gas chromatography, high performance liquid chromatography, capillary electrophoresis, combined analytical techniques, and the like. Among them, high performance liquid chromatography has a good linear relationship between peak area and mass concentration, good separation effect, high speed and high sensitivity.
Chrom-Matrix developed the InnovationTM TX HPLC for its excellent performance in drug analysis, and the DEA expert (American banned drug agency) called it a drug analysis HPLC column. InnovationTM TX is a versatile column with reversed phase, weak cation ion exchange, hydrophilicity, and can be used in 100% aqueous or 100% organic. Due to its weak cation ion exchange mechanism, InnovationTM TX is the best of all columns for the separation of basic compounds. It has a perfect peak shape for basic compounds. Its absolute efficiency and reversed-phase chromatographic column are the same, even better than reversed phase, far superior to traditional hydrophilic chromatography columns.
The separation mode of the TX chromatographic column can be flexibly changed by pH adjustment! Under acidic conditions, the TX chromatographic column can be developed by hydrophilic chromatography. Acetonitrile (pH adjusted with formic acid, ammonium formate or ammonium acetate) as a weak mobile phase, ultrapure water (pH adjusted with formic acid, ammonium formate or ammonium acetate) as a strong mobile phase, linear gradient to find optimal conditions, final fixation method . In general, TX chromatographic columns perform best only in a small range of flow ratios. Before or after, in a few cases, the peak shape may be distorted.
Under acidic conditions, the TX chromatographic column can also be developed using reversed-phase mode. Use ultrapure water (pH adjusted with formic acid, ammonium formate or ammonium acetate) as a weak mobile phase, acetonitrile (pH adjusted with formic acid, ammonium formate or ammonium acetate) as a strong mobile phase, linear gradient to find optimal conditions, and finally fixed method.
pH adjustment is always one of the most important choices for optimizing conditions. In neutral pH conditions, the reverse phase mode is more pronounced. Methanol can also be used. In practical applications, we observed many examples of not separating under one condition but succeeding at another pH.
The advantages of the InnovationTM TX HPLC are illustrated below as a drug analysis column.
Example: Purification and identification of aminorex, aminorex is a first type of banned stimulant! It has been banned for 150 horse racers in the past four years. The Jockey Club, the US FDA, the International Anti-Drug Organization, and the Veterinary Drug Group's multi-party identification: aminorex is a secondary active metabolite produced by parasitic veterinary drugs in horses, pigs, cattle and other livestock. This metabolic pathway has not been previously discovered! Chrom-Matrix InnovationTM C8+SCX Solid Phase Extraction Products, PSA Solid Phase Extraction Products, SCX Solid Phase Extraction Products, WCX and C8 HPLC Columns, TX Columns are selected for this length up to three In the appraisal process of the year, and played a vital role.
The focus of past debates is that the Amirex LC-MS/MS MRM peak (M+1=163) may be an isotope contribution of another active metabolite (M+1=162) because of reversed-phase high performance liquid chromatography. The two peaks cannot be separated. However, on the Chrom-Matrix InnovationTM TX LC-MS/MS column, the difference in peak retention time is up to ten minutes.
This shows that the InnovationTM TX column plays an important role in drug testing, which is the result of research conducted by Chrom-Matrix's research team based on years of research.