The human genome work sketch has been published for 15 years, and the whole genome of each species has also been released. Second-generation sequencing (NGS) makes genome sequencing a breeze. Can you still send CNS articles in the order? Is it whimsical? Looking back at the 2016 CNS article, the results are positive. Now sequencing can not only be done by measuring genomes and transcriptomes, but the genome data can even be analyzed together with the proteome. In this article, we take a look at this year's article published on the CNS through large-scale sequencing to see what the latest research trends are.

1 genome

Genomic sequencing

The research that can be published on the CNS is of great scientific value. What is the measurement of the genome? Why? How to measure it. There are 7 CNS articles in this year's pure genome-wide sequencing, three of which are cover articles. These 7 articles have certain characteristics:

Rare sample: icewood is more than 5,000 years ago;

Unique evolutionary status: valerian from the ocean to the land and back to the ocean; hippocampus with special body type and male parenting;

Technology milestones: Long sequencing completes the gorilla genome; third generation sequencing publishes the most continuous human genome.

Special environment: whole genome sequencing of nearly 400 Atlantic salmon in polluted waters;

A large number of samples: 10 different types of habitats, more than 125,000 viral sequences in 3,042 samples from around the world.

盘点2016年测个基因组就发表在CNS上的文章

Science: Pathogen genome 5,300 years ago

Science and Nature have reported that researchers have extracted the oldest pathogen genome from icewood that was more than 5,000 years ago. The study was published on the January 7th issue of Science. An important question addressed by this study is when the hybrid H. pylori strains carried by modern Europeans occur.

Special evolutionary status allows the psyllium genome to be placed on the cover of Nature

The sequencing and research of the marine flowering plant Zostera marina genome illustrates how marine algae evolved into terrestrial plants and then returned to the sea. On February 18th, Nature reported the results of the whole genome sequencing of Valerian by cover story, research report and news outlook. The study marks the results of eight years of work by 35 scientists from around the world, not only helping botanists analyze the evolution of alfalfa, but also promote understanding of the evolution of flowering plants in general.

The results of Chinese scientists are on the cover of Nature: Deciphering the hippocampal genome

Researcher Lin Qiang, a researcher at the South China Sea Institute of Oceanology, Chinese Academy of Sciences, led a research paper jointly completed by laboratories such as Germany, Singapore, and Huada Gene as cover story and long paper (Article) published on Nature on December 15, 2016. Lin Qiang's research team carried out genome sequencing and analysis of the tiger-tailed hippocampus, and found that hippocampus is currently the fastest-growing species in whole-genome fish. Analysis shows that the loss of hippocampal gene is related to the loss of teeth and pelvic fins. The gene is copied and the newly generated gene makes male pregnancy possible. The regulation of the original disappears and changes the skeleton, and the body is protected by bone plate.

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