US research finds a new breast cancer treatment target

December 18, 2015 Source: Technology Daily

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The study, published in the latest issue of the journal Science Translational Medicine, points out that a growth regulator called the casein kinase 1δ enzyme (CK1δ) can be used as a new therapeutic target for breast cancer. For breast cancer patients, including the intractable triple-negative breast cancer, which is not driven by estrogen, progesterone or HER-2/neu genes, the growth of CK1δ is a very common phenomenon, affecting 10% to 20% of breast cancer patients.

Studies have shown that abnormal regulation of CK1δ can activate β-catenin and increase tumor growth in breast cancer patients. --catenin is an oncogene in many cancer patients, but due to the lack of typical mutations, it is not clear that this oncogene can also be activated in breast cancer types. The researchers suspect that this may be a relationship of excessive expression of CK1δ, and the experiment proved to be the case.

They used a laboratory compound called SR-3029, which significantly blocked tumor growth in experimental animals as well as in patient tumor sections. The researchers explained that SR-3029 removed beta-catenin from cancer cells and killed the tumor.

“This is a very promising treatment option,” said William R. Roth, executive director of TSRI's medical chemistry department. “SR-3029 is being tested against a variety of cancers and hopes to be converted into clinical applications as soon as possible.”

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