Peking University Research Team: Low-dose IL-2 can treat systemic lupus erythematosus August 29, 2016 Source: Technology World Network
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IL-2 is a type of cell growth factor in the immune system that regulates the cellular activity of white blood cells in the immune system. ? The research team of Peking University People's Hospital recently applied low-dose interleukin-2 (IL-2) to treat systemic lupus erythematosus for the first time in the world. Compared with traditional immunotherapy, this low-dose IL-2 treatment did not increase infection. risks of.
Systemic lupus erythematosus is a serious systemic autoimmune disease. The disease has a high prevalence and a poor prognosis, which seriously threatens the quality of life of patients. At present, the treatment of the disease is treated with hormones and immunosuppressive agents, often accompanied by various adverse reactions such as infection and tumor.
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The study, conducted by the Li Zhanguo team of the Department of Rheumatology and Immunology of Peking University People's Hospital, in collaboration with Monash University and the Shandong Academy of Sciences, reveals the mechanism by which IL-2 regulates immune balance and treats systemic lupus erythematosus - patients with systemic lupus erythematosus There is an immune imbalance in the body, mainly manifested by the immune imbalance of effector and regulatory CD4+ T cells, and these CD4+ T cell subsets are regulated by IL-2.
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The study found that low doses of IL-2 inhibited the overactive immune response in lupus patients and reduced the attack of autoantibodies on organ tissues. Therefore, the significance of this treatment is to down-regulate the overactive immune system through various immune mechanisms, which will bring a new concept to the diagnosis and treatment of clinical immune diseases. This important research result was recently published online in Nature Medicine.
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The team's experts said that this low-dose IL-2 treatment did not increase the risk of infection compared with traditional immunotherapy. They have begun to study their immune mechanisms and, based on the characteristics of different immune diseases, have begun to use this method for the treatment of other autoimmune diseases such as rheumatoid arthritis and Sjogren's syndrome.