The important raw material medicinal lamp

February 02, 2018 Source: Science and Technology Daily

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On January 31st, the international academic journal "Nature News" published the latest achievement of Yunnan Agricultural University in the key technology development and industrialization application research of Denghuahua industry chain.

It is the core medicinal ingredient of medicinal plant breviscapine. Yunnan Agricultural University Southwestern Chinese Medicine Germplasm Innovation and Utilization National Local Joint Engineering Research Center Professor Yang Shengchao, in collaboration with the Research Institute of Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Jiang Huifeng research team, based on the sequencing of Erigeron breviscapus genome, successfully screened breviscapine synthesis The key enzyme gene in the pathway, and successfully constructed a cell factory with full synthesis of scutellarin in the cell of Saccharomyces cerevisiae. Through metabolic engineering and optimization of fermentation process, the content of scutellarin was 108 mg per liter, which was initially industrialized. Potential ability.

This achievement provides a new way to industrialize the production of traditional Chinese medicine components, and provides a new model for the modernization of traditional Chinese medicine. It is a good natural medicine for the treatment of cardiovascular and cerebrovascular diseases in the treatment of ischemic cerebrovascular disease with cerebral embolism and cerebral hemorrhage. At present, cardiovascular and cerebrovascular diseases have become the biggest threat to human life, and its morbidity and mortality have surpassed the tumor diseases and leap to the first place. The incidence of cardiovascular and cerebrovascular diseases in the elderly in China is as high as 30%. As China's social population ages, the demand for cardiovascular and cerebrovascular drugs is rapidly increasing.

Erigeron is one of the “Five Natural Series” drugs developed in Yunnan Province, and the market demand continues to grow at a rate of 15% per year. Yunnan is the main producing area of ​​breviscapus, which gathers almost all of the raw materials and extracts produced in China. The team of Professor Yang Shengchao of Yunnan Agricultural University has long been committed to the key technology research of the erigeron flower industry. He has completed the artificial domestication cultivation of breviscapus, the breeding of new varieties and the construction of GAP base. The new varieties selected for breeding have accumulated more than 100,000 mu and established cooperation with enterprises. The direct-covering and rain-proof cultivation techniques have greatly reduced the occurrence of root rot. In recent years, the research team has made outstanding research results in the sequencing of breviscapine genome, whole genome selection breeding and total synthesis of core medicinal components. (Zhao Hanbin)

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