Some commonly used non-antibacterial drugs or "double-edged swords" treatment will also affect the human flora.

March 26, 2018 Source: Science and Technology Daily

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A large-scale screening study published by Nature in the UK recently showed that about one-quarter of the commonly used non-antibacterial drugs are "double-edged swords" for humans, which affects the normal bacteria in the human body. Growing.

Drugs can have both beneficial and detrimental effects. Recent studies have suggested that specific drugs, including antidiabetic drugs, non-steroidal anti-inflammatory drugs (also known as non-steroidal anti-inflammatory drugs) and atypical neuroleptics, alter the composition of the human gut flora - despite these The drug was originally intended to act on human cells rather than bacteria. Intestinal bacteria play a very important role in human health, but the extent to which a large number of non-antibiotics affect them is still unknown.

This time, at the European Molecular Biology Laboratory in Heidelberg, Germany, researchers used bacterial cell cultures to screen more than 1,100 listed drugs, including antibacterial drugs, for representative 40 common human intestinal strains. Antiviral drugs, drugs that act on human cells, and veterinary drugs. They found that 27% of tested drugs and 24% of drugs that act on human cells (including each treatment category) inhibit at least one gut bacterial growth.

In addition, by examining past research, scientists have found that drugs targeting the human body have side effects similar to antibiotics. These findings may help optimize drug treatment, reduce side effects, and potentially use drugs that target the body as a new antibacterial or microbiome modulator.

In another related paper published online in the latest issue of Nature Microbiology, the European team of scientists presented research findings on the metabolic properties of intestinal bacteria. They cultured 96 gut bacteria through 19 different growth media. Between the closely related species, diverse growth patterns were discovered, some of which were inhibited by common intestinal metabolites, while others grew well in specific component media. The researchers say the findings are contrary to past perceptions: bacteria have complex metabolic requirements. (Reporter Zhang Mengran)

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