Hypertrophy Peptide Myostatin GDF-8 Human Growth 1mg/Vial

Product name: GDF-8 (Growth Differentiation Factor 8 Myostatin)
Purity: >98%
Specification: 1mg
Storage:2-8 degree centigrade refrigerator
Package: 10 Vials/Kit
Deliver:1 working day for ready goods,7 days to your destination.
Pacakge:1kit=10vials Alumnium foil+bubble+carton
Customized:accepted.
Country of Origin: China
 

Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and follistatin-relatedgene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.Description:28 kDa protein containing 243 amino acid residues of the human Myostatin Propeptide and 5 additional amino acid residues.

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.

Applications:

The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

Treat muscle atrophy, strengthen muscle toughness,Increase muscle number
Treating malnutrition patients is an important index of the strength training athletes
GDF-8 can effectively prevent the increased due to age brings the increase of adipose tissue, and reduce the occurrence of diabetes and obesity.

Rich experience.
Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation.

Great quality, purity and favourable.
Good quality is one of our secret success, welcome order the samples, MOQ just 10 grams.

Safe and fast delivery.
We have stock, so we can delivery quickly at the very day when receive the payment.
We have special way could ship 0.01kg to 2kg products a time. We offer melting powder into liquid service. And ship the liquid in special bottles.

Good after-sales service.
Tell the package update ASAP, and will try best solve when customer encountered various problems.

Our Service:
Payment method: Paypal, Western Union, Moneygram, TT.
Shipping method: Fedex, DHL, EMS or by SEA
Delivery time: within 3 days after payment

WHY CHOOSE US?
1, high quality with competitive price

1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery

1)Parcel can be sent out in 1 day after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 
4) Customs pass rate ≥ 99%!

3, We have clients throughout the world

1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Any inquiries will be highly appreciated, meeting customer's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
4)Best after-sales service!

 

 

Hypertrophy Peptide Myostatin GDF-8 Human Growth 1mg/Vial

Product name: GDF-8 (Growth Differentiation Factor 8 Myostatin)
Purity: >98%
Specification: 1mg
Storage:2-8 degree centigrade refrigerator
Package: 10 Vials/Kit
Deliver:1 working day for ready goods,7 days to your destination.
Pacakge:1kit=10vials Alumnium foil+bubble+carton
Customized:accepted.
Country of Origin: China
 

Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and follistatin-relatedgene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.Description:28 kDa protein containing 243 amino acid residues of the human Myostatin Propeptide and 5 additional amino acid residues.

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.

Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.

Applications:

The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

Treat muscle atrophy, strengthen muscle toughness,Increase muscle number
Treating malnutrition patients is an important index of the strength training athletes
GDF-8 can effectively prevent the increased due to age brings the increase of adipose tissue, and reduce the occurrence of diabetes and obesity.

Rich experience.
Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation.

Great quality, purity and favourable.
Good quality is one of our secret success, welcome order the samples, MOQ just 10 grams.

Safe and fast delivery.
We have stock, so we can delivery quickly at the very day when receive the payment.
We have special way could ship 0.01kg to 2kg products a time. We offer melting powder into liquid service. And ship the liquid in special bottles.

Good after-sales service.
Tell the package update ASAP, and will try best solve when customer encountered various problems.

Our Service:
Payment method: Paypal, Western Union, Moneygram, TT.
Shipping method: Fedex, DHL, EMS or by SEA
Delivery time: within 3 days after payment

WHY CHOOSE US?
1, high quality with competitive price

1)Standard: Enterprise Standard
2)All Purity≥ 99%
3)We are manufacturer and can provide high quality products with factory price.

2, Fast and safe delivery

1)Parcel can be sent out in 1 day after payment. Tracking number available
2)Secure and discreet shipment. Various transportation methods for your choice.
3)We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. 
4) Customs pass rate ≥ 99%!

3, We have clients throughout the world

1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2)Any inquiries will be highly appreciated, meeting customer's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
4)Best after-sales service!

 

 

Half Shell Mussel

Half Shell Mussel,Frozen Boiled Mussel with Shell,Frozen Half Shell Mussel

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