Model NO.: gdf 8
Other Name: Gdf-8
Package: 1mg/vial
Appearance: white powder
MF: C221H366N72O67S
Trademark: yuancheng
Transport Package: Vial/Foil Bag
Specification: 1mg/vial
Origin: Wuhan
HS Code: 3002100000
Model NO.: gdf 8
Other Name: Gdf-8
Package: 1mg/vial
Appearance: white powder
MF: C221H366N72O67S
Trademark: yuancheng
Transport Package: Vial/Foil Bag
Specification: 1mg/vial
Origin: Wuhan
HS Code: 3002100000
Gdf-8

Basic Information:
Alias: MSTN, Myostatin HMP
Purity:95%, 85%
Appearance:white powder
packing:1mg/vial

Quick Details:
 
Product Name: GDF-8
Chemical Name: Growth Differentiation Factor 8
Other Names: Myostatin
MF: C221H366N72O67S
Appearance: White Lyophilized Powder
Dry: Freeze
Payment Terms: Western Union, MoneyGram,TT, Bitcoin.
Country of Origin: China

Introduction:

Growth Differentiation Factor 8 (GDF-8), also known as myostatin, is a member of the TGF-beta superfamily that is expressed specifically in developing and adult skeletal muscle. GDF-8 cDNA encodes a 376 amino acid (aa) prepropeptide with a 24 aa residue signal peptide, a 223 aa residue amino-terminal propeptide, and a 109 aa residue carboxy-terminal mature protein. Mature GDF-8 contains the canonical 7-cysteine motif common to other TGF-beta superfamily members. Similar to the TGF-beta s, activins and BMP-11, GDF-8 also contains one extra pair of cysteine residues that is not found in other family members. The bioactive form of GDF-8 is a homodimer with an apparent molecular weight of approximately 25 kDa. GDF-8 is highly conserved across species. At the amino acid sequence level, mature human, mouse, rat and cow GDF-8 are 100% identical. Within the TGF-beta superfamily, GDF-8 is most closely related to BMP-11, a mammalian protein that acts as a dorsal mesoderm and neural inducer in Xenopus explants. The two proteins share 90% amino acid sequence identity within their mature chain. A targeted disruption of GDF-8 in mouse results in large mice with a widespread increase in skeletal muscle mass, indicating that GDF-8 is a negative regulator of skeletal muscle growth. A mutation in the bovine GDF-8 gene has been shown to be responsible for the double-muscled phenotype in cattle breeds such as Belgian Blue cattle that is characterized by an increase in muscle mass. GDF-8 has also been shown to inhibit preadipocyte differentiation to adipocytes. Mature GDF-8 binds to activin type II receptors and the binding is antagonized by the activin-binding protein, follistatin. R&D Systems recombinant GDF-8 preparations have been shown to act similarly to Activin A in both the Xenopus animal cap and the K562 assays.

Application:

1) The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

2) Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

3) Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

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Our Advantage:

1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. High Quality: 
   1)Standard: Enterprise Standard 
   2)Purity: 99%
3. Varied Payment Terms: T/T Bank Transfer, Western Union, MoneyGram and Bitcoin 
4. Competitive price: We are manufacturer and can provide  products with factory price.
5. Worldwide clients: 
    1)Professional service and rich experience make customers feel at ease.
   2)Market and goods feedback will be accepted.

 
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Gdf-8

Basic Information:
Alias: MSTN, Myostatin HMP
Purity:95%, 85%
Appearance:white powder
packing:1mg/vial

Quick Details:
 
Product Name: GDF-8
Chemical Name: Growth Differentiation Factor 8
Other Names: Myostatin
MF: C221H366N72O67S
Appearance: White Lyophilized Powder
Dry: Freeze
Payment Terms: Western Union, MoneyGram,TT, Bitcoin.
Country of Origin: China

Introduction:

Growth Differentiation Factor 8 (GDF-8), also known as myostatin, is a member of the TGF-beta superfamily that is expressed specifically in developing and adult skeletal muscle. GDF-8 cDNA encodes a 376 amino acid (aa) prepropeptide with a 24 aa residue signal peptide, a 223 aa residue amino-terminal propeptide, and a 109 aa residue carboxy-terminal mature protein. Mature GDF-8 contains the canonical 7-cysteine motif common to other TGF-beta superfamily members. Similar to the TGF-beta s, activins and BMP-11, GDF-8 also contains one extra pair of cysteine residues that is not found in other family members. The bioactive form of GDF-8 is a homodimer with an apparent molecular weight of approximately 25 kDa. GDF-8 is highly conserved across species. At the amino acid sequence level, mature human, mouse, rat and cow GDF-8 are 100% identical. Within the TGF-beta superfamily, GDF-8 is most closely related to BMP-11, a mammalian protein that acts as a dorsal mesoderm and neural inducer in Xenopus explants. The two proteins share 90% amino acid sequence identity within their mature chain. A targeted disruption of GDF-8 in mouse results in large mice with a widespread increase in skeletal muscle mass, indicating that GDF-8 is a negative regulator of skeletal muscle growth. A mutation in the bovine GDF-8 gene has been shown to be responsible for the double-muscled phenotype in cattle breeds such as Belgian Blue cattle that is characterized by an increase in muscle mass. GDF-8 has also been shown to inhibit preadipocyte differentiation to adipocytes. Mature GDF-8 binds to activin type II receptors and the binding is antagonized by the activin-binding protein, follistatin. R&D Systems recombinant GDF-8 preparations have been shown to act similarly to Activin A in both the Xenopus animal cap and the K562 assays.

Application:

1) The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".

2) Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.

3) Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.

Items you may interest:

Products name
Specification

1.
MGF
2mg / vial
 

2.
PEG MGF
2mg / vial
 

3.
CJC-1295 with DAC
2mg / vial
 

4.
CJC-1295 without DAC
2mg / vial
 

5.
PT-141
10mg / vial
 

6.
MT-1
10mg / vial
 

7.
MT-2
10mg / vial
 

8.
GHRP-2
5mg / vial

9.
GHRP-2
10mg / vial
 

10.
GHRP-6
5mg / vial
 

11.
GHRP-6
10mg / vial
 

12.
Ipamorelin
2mg / vial
 

13.
Hexarelin
2mg / vial
 

14.
Sermorelin
2mg / vial
 

15.
Oxytocin
2mg / vial
 

16.
TB500
2mg / vial
 

17.
Pentadecapeptide BPC 157
2mg / vial
 

18.
176-191
2mg / vial
 

19.
Triptorelin
2mg / vial
 

20.
Tesamorelin
2mg / vial
 

21.
Gonadorelin
2mg / vial
 

22.
Gonadorelin
10mg / vial
 

23.
DSIP
2mg / vial
 

24.
Selank
5mg / vial


Our Advantage:

1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. High Quality: 
   1)Standard: Enterprise Standard 
   2)Purity: 99%
3. Varied Payment Terms: T/T Bank Transfer, Western Union, MoneyGram and Bitcoin 
4. Competitive price: We are manufacturer and can provide  products with factory price.
5. Worldwide clients: 
    1)Professional service and rich experience make customers feel at ease.
   2)Market and goods feedback will be accepted.

 
Related products:
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Benzocaine 94-09-7
Benzocaine HCI  
Lidocaine 137-58-6
Lidocaine HCI 73-78-9
Procaine 59-46-1
Procaine HCI 51-05-8
Prilocaine 721-50-6
Prilocaine HCI 1786-81-8
Tetracaine 94-24-6
Tetracaine HCI 136-47-0
Bupivacaine 2180-92-9
Bupivacaine HCI 14252-80-3
Levobupivacaine Hydrochloride 27262-48-2
Pramoxine HCI 637-58-1
Proparacaine HCI 5875-06-9
Articaine HCI 23964-57-0
Mepivacaine HCl 1722-62-9
Larocaine 94-15-5
Ropivacaine HCI 132112-35-7/98717-15-8
Dibucaine HCI 61-12-1

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