Release date: 2017-08-15 Anticancer agents are widely used, but they have side effects such as fatigue, muscle pain and even myocardial atrophy. A recent study in Japan found that the anticancer agent doxorubicin can cause myocardial atrophy, and it is expected to develop drugs that inhibit the side effects of anticancer agents. Source: Xinhua News Agency Video Door Phone,Intercom System For Multi Apartment,Ip Video Door Phone System,Video Door Phone Made In China,Video Intercom Zhuhai Mingke Electronics Technology Co., Ltd , https://www.zhmkdz-electronics.com
Doxorubicin is a drug used to treat cancers such as breast cancer, lung cancer and bladder cancer, but it also causes irreversible heart damage to the user. Researchers at the Institute of Physiology and the University of Kyushu have injected doxorubicin into experimental mice and found that a protein called TRPC3 is present in the myocardial cell membrane.
This protein causes excessive amounts of reactive oxygen species in the heart, causing problems such as myocardial atrophy and poor heart function. The researchers further tested and found compounds that inhibit the production of reactive oxygen species by TRPC3 proteins. The researchers applied this compound to doxorubicin in experimental mice. The mice did not have problems such as myocardial atrophy and ventricular dysfunction.
Researchers say the findings will help people develop new drugs that inhibit the side effects of anticancer agents such as doxorubicin. Related papers have been published in the online edition of the American academic journal Clinical Examination Journal.