Recently, "Multiple Sclerosis Journal" published a new study from the University of Exeter in the United Kingdom. The study found that patients with multiple sclerosis are more likely to infect a toxin that is usually found in sheep.

Multiple sclerosis (MS) affects about 2.3 million people worldwide. MS affects the central nervous system (CNS) and may cause a range of symptoms that usually involve movement, feeling, balance, and vision problems. Symptoms usually appear at the age of 20 or 30. Some people can be controlled in their condition, and in some cases, the progress of the disease can be slowed down. However, there is still no cure.

Finding the reason

MS is an autoimmune disease in which the immune system attacks other healthy tissues (central nervous system). Genetic and environmental factors are thought to be related to it, but the exact cause is not known.

Recently, a group of researchers at the University of Exeter in the United Kingdom have discovered an astonishing problem that may be able to find clues about the origin of MS: sheep.

As early as 2013, a U.S. research team noticed that some patients with MS had an increased level of antibodies called ε toxin (ETX). In other words, ETX enters their body and triggers an immune response, producing antibodies. If the toxin is encountered again, the antibody will initiate the attack.

This toxin is produced by Clostridium perfringens and it is found in domestic animals, the most common being sheep. ETX passes through the intestinal wall and accumulates in the kidneys and brain. Once in the brain, it can destroy myelin and also affect the nerves and myelin-producing cells. In sheep, this type of ETX poisoning is known as enterotoxaemia or serous kidney disease.

Myelin sheath is a waxy layer that covers many nerve cells and transmits signals quickly and efficiently. In MS, myelin and the cells that make it are destroyed by the immune system.

This striking similarity between enterotoxemia and MS makes any potential relationship worth further study.

Look for ETX antibodies

After the earlier study, Professor Titball, the study leader, and the team examined the blood of MS patients and controls without MS. They used two different sampling methods to measure the level of ETX antibodies to ensure accuracy. They found that 43% of MS patients had ETX antibodies, compared with only 16% of controls.

Of course, these are early discoveries and more work is needed to eliminate the exact details of this relationship. In addition, it is worth noting that some control groups also carry these antibodies and they do not develop MS. Therefore, other factors are definitely involved.

However, Slater hopes this is the beginning of effective treatment. "If the link between ε toxin and MS is confirmed, then this suggests that vaccination is an effective treatment for prevention or early disease. ε toxin is very effective, but human vaccine has never been developed." Compile


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