Innovative infection control methods are expected to replace antibiotics

“With the emergence of the super bacterial group, human innocence may be hopelessly saved.” At the Third Military Medical University Chongqing Daping Hospital, the National Symposium on Microbial Toxins and Trauma Infections and the Eighth Sepsis At the summit forum, Sheng Zhiyong, an academician of the Chinese Academy of Engineering, called for the urgent task of prevention and treatment of wound infections to study and promote new methods to replace antibiotics.

Experts proposed a strategy for the use of probiotic bacteria to produce bacteria and regulate specific and non-specific immunity to treat bacteria, poisons, and inflammations in response to sepsis and multiple organ dysfunction caused by traumatic infections. The results of research on systemic inflammation caused by the use of traditional Chinese medicine preparations, screening of Chinese herbal medicines, and novel anti-inflammatory peptides, and multi-target treatment of pathogenic bacteria infections issued by the conference with Chinese independent intellectual property rights were unanimously recognized. The research results are currently being promoted.

The prevention and treatment of wound infections has always been a hot issue in the field of international trauma surgery. "However, with the widespread use of antibiotics, Gram-negative G-bacilli represented by Escherichia coli and Pseudomonas aeruginosa have gradually replaced the streptococcus and Staphylococcus aureus since the 1960s and 1970s. Lanyang-positive G+ cocci is the main pathogen of wound infection.” Sheng Zhiyong introduced that by the 1970s and 1980s, there was a significant increase in spore-free anaerobic bacteria, some new pathogens and various molds, and Serratia marcescens The "non-pathogenic bacteria" such as Klebsiella, aerobic bacilli, anachobacter pyogenes, and acinetobacter are constantly emerging, while anaerobic bacteria are involved in mixed infections and fungi such as Candida albicans, Aspergillus, Mucor and other infections. Also increasing. Since the beginning of 1995, the G+ cocci, represented by S. aureus, has returned, and the infection rate has exceeded 50% of clinical infection cases and has become the main pathogen of wound infection. "Currently, infections caused by methicillin- and vancomycin-resistant staphylococci and Acinetobacter baumannii have constituted a serious clinical threat."

At present, the emergence of drug-resistant bacteria has intensified, and the human research and suppression of these drug-resistant bacteria are far behind the emergence of new drug-resistant bacteria. "So, the only way to deal with antibiotic resistance is to develop new treatments and try not to use antibiotics," said Sheng Zhiyong.